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In the foundational 2017 Cell study, naturally aged mice and chemotherapy-treated mice received FOXO4-DRI at 5 mg/kg by intraperitoneal (IP) injection , given on an intermittent schedule (about three times per week) across several weeks

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292 Reduced membrane-associated RING finger protein 2 (March 2) disrupts its interaction with PKM2, altering glucose metabolism and increasing lactate production, which enhances H3K18la and p53-mediated apoptosis in VSMCs, worsening aortic aneurysm/dissection

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Under oxidative stress, autophagy protects mitochondrial integrity by clearing ROS, preventing cell apoptosis, and exerting a protective effect (95)