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2D and Supplementary Fig

In order to determine whether the effect of GH is direct in AgRP cells (independent of action potential-mediated synaptic transmission), a new set of recordings was performed in the presence of the voltage-gated sodium channel antagonist tetrodotoxin (TTX

The dose-response relationship was clear across the REDEFINE 2 trial's range of 0.3 mg to 4.5 mg weekly, with higher doses consistently producing greater weight reductions

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Once opened keep refrigerated and use within 2 months