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Drowsiness, weakness Nerve injury accompanied by tingling and numbness in the hands and legs Loss of memory, confusion Dementia Depression Seizures Recommended Amounts of Vitamin B12 For men and women 14 years of age and older, the Recommended Dietary Allowance (RDA) is 2.4 micrograms (mcg) per day

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Estrogen has been shown to upregulate endogenous MOTS-c expression in preclinical models, which may partly explain why metabolic deterioration accelerates in perimenopause when estrogen falls precipitously [2]