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A slow clatter, increasing, faster, faster, faster, the rails clicking by, the structure of the train groaning as something impossible happening, and something so utterly vast was compelled to move because of a delicately contained explosion

On Day 1, all participants smoked a single preferred brand of conventional cigarette (not randomised) with puffs taken at 30-s intervals

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The provision not only of nicotine-replacement products but of schedules, structure and professional encouragement for gradual quitters likely optimized those participants likelihood of success, the researchers said