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Even if it is still unclear whether OS is a primary or a secondary cause of neurodegeneration in ALS, overwhelming evidence indicates the pathological role of OS, and alterations in KEAP1 and NRF2 expression and in KEAP1-NRF2 activity may explain the progressive MN degeneration and death associated with ALS [170]

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What you should not see: Visible white or colored particles floating in the solution Persistent cloudiness that doesn't clear with gentle swirling Gel-like consistency or viscous clumps Significant color (pink, brown, or orange tints indicate degradation or contamination) If the solution looks cloudy or has particles after 30+ minutes of attempted dissolution, do not inject it