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The theoretical advantage is significant

Subcutaneous Fat Targeting Visceral adipose tissue (VAT), located deep in the abdominal cavity surrounding internal organs, differs substantially from subcutaneous adipose tissue (SAT), which lies beneath the skin

These trials included both single-dose pharmacokinetic studies and long-term efficacy trials extending up to 24 weeks of continuous administration

The model identifies pathways responsible for the effect of the double and triple drug combinations, versus the effect of the addition of each single agent at its IC50 concentration

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