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[57] The Indigenous population of Peru decreased from about 9 million in the pre-Columbian era, to 600,000 in 1620

These characteristics, together with its well-established efficacy for the treatment of schizophrenia, the lower risk of extrapyramidal side effects compared to first-generation antipsychotics, and the lower risk of metabolic side effects compared to most second-generation antipsychotics [17], make aripiprazole an attractive alternative for the treatment of patients with schizophrenia with coexisting SUDs