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5-Amino-1MQ is a small molecule membrane-permeable inhibitor of the enzyme Nicotinamide N-methyltransferase (NNMT)

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(Scientific Reports, 2022) showed that the combination of 5-Amino-1MQ + caloric restriction establishes a distinct cecal microbial profile, normalizing the microbiome to the levels of lean control mice, whereas caloric restriction alone fails to do so

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