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Other mitochondrial citrate cycle enzymes, such as alpha-ketoglutarate dehydrogenase and isocitrate dehydrogenase can also be activated by Ca 2+ [21, 22]

Collectively, these non-canonical receptors expand the LPA signaling network and offer new potential targets for prostate cancer therapy

No lethal dose identified at doses up to 20 mg/kg in animal studies No organ toxicity observed across multiple organ systems Negative mutagenicity testing across standard assays No teratogenic effects in pregnancy studies Limited long-term human data beyond 6 weeks Theoretical Considerations The primary theoretical concern relates to BPC-157s angiogenic properties

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