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417 The PerR regulatory site binds Fe II and Mn II and both function as corepressors

98 Melatonin is thought to reduce tinnitus by protecting hair cells (sensory cells in the ear responsible for hearing) from oxidative damage, promoting normal blood flow to inner ear structures, relaxing ear muscles, attenuating depression and anxiety, inhibiting the stress response, and supporting normal sleep patterns

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For example, you use your arms and legs in activities like jumping and running