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Additionally, in a 30-day placebo-controlled trial in 300 adults (aged 18-65 years), supplementation with the B vitamins (at doses of about 3 to 13 times the RDA, excluding folic acid), vitamin C (1,000 mg/day), calcium (100 mg/day), and magnesium (100 mg/day) was associated with significant improvements in various scores of psychological stress compared to a placebo (139)

For individuals with insulin resistance and DM, the viewpoint of Corona et al indicates that metformin, glucagon-like peptide-1 agonist, and sodium-glucose cotransporter-2 inhibitor are more effective in improving ED [167]

Most people start noticing improvements in 4-8 weeks with consistent use

The most common side effect is minor swelling or redness from the needle used in the injection

Therefore, B12 deficiency should be excluded or treated before starting folic acid in patients with unexplained anaemia or neurological symptoms