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These functional protective effects are consistent with metaproteomic findings in children with recent-onset T1D (188), where gut microbiota dysregulation (including reduced butyrate-producing taxa) correlates with -cell damage severity, supporting a clinical link between butyrate deficiency and T1D pathogenesis

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Jennifer LaSalle, a 44-year-old gym owner, said achieving her current level of fitness took about a decade of consistent effort