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These modifications collectively address the major limitations of natural amylin - its tendency to aggregate into toxic fibrils, rapid degradation, and poor pharmacokinetic properties - while preserving and enhancing its beneficial metabolic effects

It can withstand the acidic environment of the stomach without breaking down, which explains why oral formulations exist alongside injectable versions

Hydrophilicity barriers: Peptides generally hydrophilic due to charged amino acids

Vitamin B12 is a water-soluble vitamin, meaning it dissolves in water and is quickly absorbed by the body