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Abbreviations: ABC ATP-binding cassette ACAT acyl-CoA:cholesterol acyltransferase APC antigen presenting cell AUC area under curve BCRP breast cancer resistance protein BMP-2 bone-morphogenic protein 2 CK creatine kinase CKD chronic kidney disease CoQ10 co-enzyme Q10 CYP450 cytochrome P450 DAMP damage associated molecular pattern DHB 6,7-dihydroxybergamottin eNOS endothelial nitric oxide synthase FOXO forkhead box class O FPP farnesyl pyrophosphate FTase farnesyltransferase GGPP geranylgeranyl pyrophosphate GGTase I gernylgernayltransferase I GGTase II geranylgeranyltransferase II GTP guanosine triphosphate HMGB1 high mobility group box 1 HMG-CoA 3-hydroxy-3-methylglutaryl coenzyme A HMGF hydroxy methyl glutaryl flavonoids HMGR HMG-CoA reductase ICAM-1 intracellular adhesion molecule-1 IRS-1 insulin receptor substrate-1 LDL low-density lipoprotein LDL-C low-density lipoprotein cholesterol LFA-1 lymphocyte function-associated antigen 1 Mac-1 macrophage 1 MEF-2 myocyte enhancer factor-2 MHC major histocompatibility complex MLCP myosin light-chain phosphate MMP matrix metalloproteinase MRP2 multidrug resistant-associated protein NO nitric oxide NLRP3 Nod-like receptor family pyrin domain containing 3 SMC smooth muscle cell OATP organic anion transporting polypeptides OSX osterix OCN osteocalcin ox-LDL oxidized LDL PAMP pathogen associated molecular pattern PDK pyruvate dehydrogenase kinase PI3K/Akt phosphatidylinositol-3-kinase/Akt Pg-P P-glycoprotein PPA receptor- peroxisome proliferator-activated receptor alpha PPA receptor-2 peroxisome proliferator-activated receptor 2 PTEN phosphate and tensin homology ROCK Rho kinase FGF fibroblast growth factor ROS reactive oxidative species SINAM statin-induced necrotizing autoimmune myopathy TF tissue factor TG triglycerides TGF- transforming growth factor-beta TL receptor toll-like receptor ULN upper limit of normal VLA4 very late antigen 4 Footnotes Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication

(Without insurance, a months supply can range between $50 to $100.) A single course of treatment does not yield permanent results: The duration of the effect will vary from person to person

Conclusions of a WHO Technical Consultation on folate and vitamin B 12 deficiencies

The optimal frequency and dosage varies person to person