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Binding the key Cys residues of the Keap1 protein by ROS or electrophilic species causes conformational changes in the target protein, which then releases Nrf2 and is no longer ubiquitinated

Upon activation, MAPK subsequently phosphorylates and stimulates multiple downstream objects, including TFs (Transcription Factors), other kinases as well as cytoskeleton linked proteins [110]

doi: 10.1186/s11671-021-03553-8 81 SafdarpourS.EftekhariZ.EidiA.DoroudD

258 , L30812 (1990)

Especially for within-individual monitoring, both are reliable kidney function tests for detecting both acute and chronic declines of kidney function [3]