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TNF-α and IL-6 production with IC50s of 1
Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development
JNK2 and JNK3
a key intermediate in peptidoglycan biosynthesis
Erastin also disrupts mitochondrial permeability transition pore (mPTP) with anti-tumor activity
anti-NLRP3/NALP3, mAb (Cryo-2) Protein A/G Magnetic Beads TNF-α and IL-6 production withThe inflammasome is a multiprotein complex that mediates the activation of caspase 1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL) 1? and IL 18. Members of the Nod like receptor family, including NLRP3 NALP3, are critical components of the inflammasome that link danger signals to caspase 1 activation. Defects in NLRP3 are the cause of familial cold autoinflammatory syndrome type 1 (FCAS1), Muckle
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