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When AOD-9604 binds to or modulates these receptors, it preferentially activates fat cells while having minimal effects on other tissues that primarily express beta-1 and beta-2 adrenergic receptor subtypes

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The most cited mechanistic finding is the Neelakantan and colleagues 2018 study in Biochemical Pharmacology , in which the investigators reported that 5-Amino-1MQ reverse[s] high fat diet-induced obesity in mice through selective inhibition of the NNMT enzyme, with measurable reductions in adipose tissue mass, improvements in insulin sensitivity, and increases in adipose tissue cellular metabolic activity in C57BL/6 mice fed a 60% kcal-from-fat diet [1]