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Since vitamin B 12 is a determinant of homocysteine metabolism, it was suggested that the risk of osteoporotic fractures in older subjects might be enhanced by vitamin B 12 deficiency

Pathogenic Th17 produces pro-inflammatory cytokines including IL-17A, IL-17F, IL-21, IL-22, and IL-26, which play a key role in the pathogenesis of chronic immune diseases (111).Non-pathogenic Th17 secretes IL-10 to negatively regulate the immune response (112)