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doi: 10.3389/fphys.2026.1760997 Received 04 December 2025 Revised 18 February 2026 Accepted 23 February 2026 Published 20 March 2026 Volume 17 - 2026 Edited by Lars Knudsen, Hannover Medical School, Germany Reviewed by Svetlana Guryanova, Institute of Bioorganic Chemistry (RAS), Russia Ana Maria Jaramillo, University of Kansas Hospital, United States Updates Copyright 2026 Costello and Birket

However, symptoms are far more likely to be related to underlying conditions that cause B12 elevationsuch as liver disease, kidney dysfunction, or haematological disordersrather than the elevated B12 itself