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The NF-B signaling pathway, activated in 80% of RA synovium, drives cytokine production, while the Janus kinase (JAK)/signal transducers and activator of transcription (STAT) pathway mediates IL-6 signaling, contributing to chronic inflammation (11)

Yeast 27:103114 Muthukumar K, Rajakumar S, Sarkar MN, Nachiappan V (2011) Glutathione peroxidase3 of Saccharomyces cerevisiae protects phospholipids during cadmium-induced oxidative stress

9 AT targeted against the mitochondria The mitochondria are significant producers of reactive species, and mitochondrial damage is one of the major contributors to the onset of various diseases and aging