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This low-grade systemic inflammation: Impairs insulin receptor signalling, directly worsening insulin resistance Damages ovarian granulosa cells, impairing egg development and ovarian function Disrupts gut barrier integrity, contributing to what some researchers call a "leaky gut" pattern associated with systemic inflammation Amplifies HPA axis dysregulation, raising cortisol and further disrupting sex hormone balance Chronic inflammation is both a consequence of PMOS and a driver that perpetuates it

doi: 10.3389/fimmu.2022.904669

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Partial squats, glute bridges, and single-leg exercises on the uninjured side

During this taper, implement aggressive lifestyle strategies: establish consistent meal patterns, maintain protein intake, continue resistance training, and develop hunger management strategies that do not rely on pharmaceutical appetite suppression