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Cytokine modulation Beyond its effects on Tregs, thymosin alpha-1 directly reduces the production of IL-1beta and TNF-alpha, two cytokines central to psoriasis pathology

South Med J 1988

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Moreover, markers of senescence, such as SA--gal and SASP, have been detected in patients treated with IR [91]

In addition, a deficiency of vitamin B12 can cause facial signs such as hyperpigmentation (dark spots), vitiligo (white patches where skin loses color), or angular stomatitis (inflammation at the corners of the mouth)