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Keep unopened vials frozen, reconstitute with bacteriostatic water only when a study calls for it, and refrigerate the reconstituted solution for short-term use

Albeit, such macrophage ablation studies must be interpreted with caution, as in a recent study, the anti-inflammatory effects of clodronate liposomes in arthritis models were attributed to the modulation of neutrophil effector functions after phagocytosis of liposomes (103)

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doi: 10.1056/NEJMoa1816714

Hashimotos thyroiditis: Epidemiology, pathogenesis, clinic and therapy