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Studies have suggested that long-term use of VLCKD for refractory epilepsy may be related to the development of hypothyroidism, with an effect seen in various populations

This method is applied when the absorption and speed of drugs are not easy to evaluate by blood drug method and urine drug method, and the effect of drugs is quantitatively related to the amounts of drugs retained in the body, allowing for relatively straightforward quantitative measurement

This is the usual dosage recommended in most common treatment cases

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At least two studies suggest that SFs neuroprotection may stem from decreased BBB permeability, improved cell survival, and/or enhanced aquaporin-4 (AQP4) channel presence