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The short treatment time was chosen as a reference for the investigation purpose (to maintain a relatively neutral pH, reasonable quantities of reactive species and operational safety) but could be prolonged if needed
Further, the antioxidant is also responsible for an increased conversion of Eumelanin to Pheomelanin (responsible for imparting the yellow-red color), thereby lightening the skin tone significantly
2019;3:nzz044
If you have known MTHFR mutations, a history of poor response to cyanocobalamin, or strong preference for methylcobalamin, seeking a formulation with that form is reasonable