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Identification of temperature-sensitive dnaD mutants of Staphylococcus aureus that are defective in chromosomal DNA replication

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The lethal dose in humans would be approximately 21,000mg for a 70kg person, making the 1-3mg daily doses used in typical protocols extremely safe from a toxicity standpoint

For NAC, the standard dosage ranges from 600-1,800 mg daily, with some research supporting safety at doses up to 2,000 mg