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The challenge is Fe 3+ can not only oxidize Pb 0 , but also oxidize I which leads to the formation of I 0

In some embodiments, the otoprotectant is a compound of Formula (V) having the structure of Formula (Va): In some embodiments, the otoprotectant is a compound of Formula (VI): wherein: X is a pharmaceutically acceptable counterion

Prolonged vomiting or diarrhoea can lead to dehydration and, in some cases, acute kidney injury (AKI)

however, heart failure with reduced ejection fraction also has a regional cause

There is no established evidence that continuous use is either necessary or safe over long horizons