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Audiences have become more appreciative of Chase's audacious storytelling decision and his biting commentary on unknowability and mortality, but that hasn't stopped die-hard fans from studying every line reading as evidence that can support a verdict regarding Tony's fate in the series finale, "Made in America." Chase is reticent to fill in the blanks, imploring fans to embrace the value of open-ended interpretation , but there are enough hints sprinkled throughout The Sopranos ' seven seasons that suggests that Tony was mercilessly killed in front of his family at Holsten's

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The paper in PLOS Medicine was in fact part of her PhD dissertation