Protection of NRK-52E cells, a rat renal proximal tubular cell line, from chemical-induced apoptosis by overexpression of a mitochondrial glutathione transporter
Biochemistry and Synthesis Meister A, Anderson ME
The endpoint of the trial was reached when the tumors grew to the size limit (15 mm in diameter)
Altogether this provided rationale for investigating the potency of FOXO4-DRI on tubular senescence and renal function in in vivo
Polyphenol-based dietary antioxidants ameliorate T2D either by (1) an insulin-dependent approach, i.e ., by protecting the pancreatic islet -cell and promoting its proliferation while reducing OS and -cell apoptosis, which causes activated insulin signaling and secretion (2) an insulin-independent approach, i.e., decreasing the intestinal absorption of glucose, inhibiting the activity of digestive enzymes and regulating glucose discharge from the liver (3) modulating intracellular signaling pathways and (4) modulating gene expression [33] (Fig