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16,17 The accelerated development of the NADs field has relied on innovations and breakthroughs in foundational technologies, such as chemical synthesis, site-specific modifications, and delivery techniques

Besides various therapeutic and pharmacological treatment options, numerous procedural treatments including laser therapy, light therapy, and microneedling have been considered in melasma treatment (Kwon et al., 2019)

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This route can achieve very high purity and a welldefined product profile, making it attractive for laboratory use, specialty pharmaceutical intermediates, and situations where precise control of impurities is critical, though at a higher production cost and smaller scale

NL, YR, and PO: writing