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Additionally, a large survey of over 2000 transmasculine patients on TRT revealed the following: 33.3% developed acne with injected testosterone 48.6% experienced acne with transdermal testosterone So while incidence varies, multiple studies suggest variables like dosage, duration, and genetics impact acne risk

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Depigmentation and/or subcutaneous atrophy can occur in thin patients, especially those with dark skins, and they should be informed of this before giving consent