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He targets genetic variants (like the MTHFR gene) that hinder the body's ability to convert synthetic folic acid into active methylfolate, and points to deficiencies in cofactors like methylcobalamin (B12) and P-5-P (B6)

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To mitigate this limitation, several strategies have been proposed, such as surface functionalization/coating (e.g., PEGylation, or solgel layers) and dynamic pre-saturation of PDMS with the compound of interest, or the use of alternative fabrication methods and materials, like thermoplastics (e.g., cyclic olefin copolymer, polymethyl methacrylate) or 3D-printed resins, that exhibit reduced molecular adsorption (79, 8386)

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Measures acquisition + retention