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High-performance liquid chromatographic assay of the methyl and nucleotide metabolites of 6-mercaptopurine: quantitation of red blood cell 6-thioguanine nucleotide, 6-thioinosinic acid and 6-methylmercaptopurine metabolites in a single sample

A total of 19 differentially regulated protein spots were identified, of which 18 spots were up-regulated and 1 spot was down-regulated in non-splenectomized -thalassemia/HbE as compared to normal controls (Fig

Lifestyle factors need to be considered as well

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