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A phase II clinical trial (NCT03666325) aims to study the fighting of primary and secondary resistance with Immunotherapy after EGFR inhibitors in locally advanced or metastatic squamous cell carcinoma [227]

By disrupting the interaction between FOXO4 and p53, FOXO4-DRI reactivates apoptosis in aged cells, clearing them from tissues and promoting systemic rejuvenation (1, 2)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 28.Gould L, Abadir P, Brem H, et al