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Its broad spectrum of biological activity has drawn significant interest within the scientific and medical communities, particularly regarding its potential use in the treatment of injuries, chronic disorders, and inflammatory conditions

Cisplatin was diluted in DI water to a 5 mM stock solution

267 While there is a need in clinical research to enroll a more homogeneous patient population, this approach raises concerns about the clinical relevance of such studies for the truly heterogeneous IC/BPS population

Ketone ester treatment of the 3xTgAD Alzheimers mice reduced the hippocampal mitochondrial [NAD + ]/[NADH] as indicated by the reduced acetoacetate/beta-hydroxybutyrate that changed from 9.3 to 3.4 (2.7-fold decrease), while there was no significant change in this ratio in the cerebral cortex (Pawlosky et al., 2017)

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