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In conclusion, mitochondria function as central hubs for energy metabolism and signaling, interacting with cellular organelles to meet the energy requirements and antioxidant defense needs during follicular development

Clioquinol, a halogenated 8-hydroxyquinoline derivative, has been found to regulate iron homeostasis in tissues by effectively chelating Fe 2+ , thereby inhibiting ferroptosis (227)

And that's exactly why a 2025 systematic review matters

In fact, studies prove that low selenium cuts testosterone production by 15-35%, with older animals showing worse effects