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Agents that shift Hb oxygen affinity present some concerns of potential negative effects as the bound oxygen cannot be off loaded in tissues with high oxygen requirements, particularly concerning in a disease characterized by decreased oxygen delivery (Hebbel and Hedlund, 2018

it does not contain nanoparticles or synthetic adjuvants

2006 Apr;5(2):97-108

Citicoline in acute ischemic stroke: A randomized controlled trial

It is the clinical context that determines whether the peptides mechanism is directed at the right problem, at the right intensity, for the right duration