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Accordingly, in mice fed a MCD diet, B cell deficiency was associated with reduced circulating anti-OSE IgG levels and decreased hepatic recruitment of CD4 + and CD8 + T cells (162)

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A novel, potent and selective PDE9 inhibitor (IMR-687) has been shown to increase levels of cGMP and HbF without signs of myelosuppression in cell lines of patients with SCD