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Thiazide and thiazide-type diuretics are foundational therapies for the management of hypertension, whereas loop diuretics are often needed for volume overload, which might also require combination therapies

These effects often diminish over time as patients adjust to therapy

Dihexa's primary mechanism is activation of the HGF/c-Met signaling pathway (hepatocyte growth factor / its receptor c-Met)

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The recovery of respiratory Complex I activity and membrane potential was significant after NAC treatment while that of ATP synthesis and activities of Complex IV and the matrix enzyme, aconitase was negligible in GSH-depleted cells