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Toxicol Mech Methods 28:467473 Ezhilarasan D (2021) Hepatotoxic potentials of methotrexate: understanding the possible toxicological molecular mechanisms

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The KIT gene controls mast cell creation from stem cells in the bone marrow, and mutations in KIT cause excess mast cell proliferation.[ref][ref] A mastocytosis diagnosis is either systemic mastocytosis (affecting the whole body) or cutaneous mastocytosis, which has more skin-related symptoms