tobacco in mouth called Smoker's palate Smoker's palate refers to changes the mouth, particularly the hard palate, due to prolonged use. It often appears as a thickened, whitish, or leathery area with red spots Dipping tobacco - Wikipedia

Hormonal Changes Women undergoing substantial hormonal changes (such as pregnancy, menopause, or menstruation) may experience palpitations

Not processed nicotine

We used risk ratio (RR) and risk difference (RD) instead of odds ratio (OR) because the use of RR and RD can better reflect the relative and absolute probability change in smoking cessation in the presence of e-cigarettes

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