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The age-related drop in NAD+ levels is caused by rising levels of CD38, a membrane-bound NADase that degrades both NAD+ and its precursor nicotinamide mononucleotide, according to a 2016 study in mice, which exhibit age-related declines in NAD+ levels similar to those seen in humans (7)

doi: 10.1021/jf011702q 216 TruongTTGardnerDK

Low IGF-1 levels correspond with high body fat and vice versa.8 Routes of administration Sermorelin is most often administered via subcutaneous injection, as are most therapeutic peptides

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Dietary fibers such as fructo-oligosaccharides (FOS) and galacto-oligosaccharides (GOS) can enhance the gut's production of secondary BAs and SCFAs, both of which support intestinal integrity and may reduce neuroinflammation (Salminen et al., 2021)