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Based on the TNBC unique metabolic phenotype, there are many existing researches focus on the metabolic interference in chemotherapy resistance models and spontaneously metastatic preclinical models (304, 305)

arguments against the use of oral cobalamin Oral treatment may be considered in certain situationsfor example, in mild or subclinical deficiency with no clinical features and when absorption and compliance are definitely not a problem

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Notably, the NF-B inhibitor BAY 117082 alleviated RSL3-induced ferroptosis both in vitro and in vivo , indicating the critical role of this pathway

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