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Evaluating what that language means in practice requires understanding what would be needed to substantiate it and what ProHealth can point to as quality differentiators

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Drop back to the last tolerated dose and stay there for 6-8 weeks before attempting escalation again

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Ligand geometry constraints Rigid or semirigid ligands influence the coordination geometry of metal complexes in two main ways: Bulky rigid ligands that crowd the metal center prevent other ligands from binding